The E3 ubiquitin ligase FBW7 plays critical roles in multiple pathological and physiological processes.Here, we report that after high-fat diet (HFD) feeding for 16 weeks, myeloid-specific FBW7-deficient mice demonstrate increased redox stress, inflammatory responses and insulin resistance.Macrophages activation under FBW7 deficiency decreases subs
Spectral unmixing is an important technique for quantitatively analyzing hyperspectral remote sensing images.Recently, constrained nonnegative matrix factorization (NMF) has been demonstrated to be a powerful tool for spectral unmixing.However, acquiring the problem-dependent prior knowledge and incorporating it into NMF as effective constraints is
Attempting to create greater understanding of the political dynamics that influence domestic disaster relief and management (DRM) in Thailand, this article takes a closer look at these dynamics by outlining the main actors involved in flood-related DRM.It acknowledges the importance of international and military actors but emphasises the role of na
The Soup Kettle Warmers mechanical behavior of the extruded 7003-T6 aluminum profiles used as automotive buffer beams is investigated.The correlation of the texture and the formation of the adiabatic shear band is analyzed.Copper texture, R texture, and S texture are the main reasons for the anisotropy of mechanical behavior of the profile, resulti